期刊
CARBOHYDRATE POLYMERS
卷 88, 期 1, 页码 46-53出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.11.058
关键词
Gellan gum; Oxidation; Carboxymethyl chitosan; Hydrogel; Tissue engineering
资金
- National Natural Science Foundation of China [81071272]
- Research Fund for the Doctoral Program of Higher Education of China [0900905111001]
Gellan gum is a candidate material for cartilage tissue engineering, but its application is limited by the high gelation (Coutinho et al., 2010) temperature and lack of mechanical strength. In this study, oxidized gellan gum was prepared and mixed with carboxymethyl chitosan to form a double-network complex hydrogel with significantly improved gelation temperature (T-gelation) and mechanical properties. The T-gelation was lowered from 42 degrees C to below physiological temperature by oxidation, and further reduced by complexing with carboxymethyl chitosan. The complex hydrogel showed an increased compressive modulus 01 278 kPa, and an ability to return to the original shape after release of the compressive load. In vitro chondrocytes encapsulation and proliferation experiments found that the complex hydrogel significantly enhanced the viability of the cells. These results suggest that, the complex gel of gellan gum and carboxymethyl chitosan is a promising material for cartilage tissue engineering. (C) 2011 Elsevier Ltd. All rights reserved.
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