期刊
CARBOHYDRATE POLYMERS
卷 90, 期 1, 页码 109-115出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.05.002
关键词
Alginate; Silver nanoparticles; Sponge; Antimicrobial activity; Proinflammatory cytokines
资金
- BioMedical Research Institute grant, Kyungpook National University Hospital
- National Institute of Crop Science, Rural Development Administration, Republic of Korea [PJ0073852010]
Silver-based biomaterials have been developed in a variety of bactericidal applications, especially for wound dressings. In this study, silver nanoparticles (AgNPs) were synthesized in a sodium alginate solution and then the composite sponge containing AgNPs was prepared from the nanocolloid solution. The alginate-stabilized AgNPs had the mean negative zeta potential of -52.5 mV, suggesting that the surface charge prevents the nanoparticles from aggregating through electrostatic repulsion. The alginate-AgNPs composite sponge had a highly enhanced antimicrobial activity compared to the alginate sponge. In spite of excellent cytocompatibility of the alginate sponge, the viability of the cell treated with the alginate-AgNPs composite sponge extract decreased to 86% of the control. The amount of proinflammatory cytokines released from macrophages treated with the alginate-AgNPs composite sponge was reduced. For the preparation of AgNPs-embedded composites, alginate can be a potential candidate stabilizing AgNPs and providing synergistic antimicrobial and antiinflammatory activities with AgNPs. (C) 2012 Elsevier Ltd. All rights reserved.
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