期刊
CARBOHYDRATE POLYMERS
卷 87, 期 2, 页码 1192-1198出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.08.096
关键词
Chitosan; Polysaccharide; Biomaterial; Reacetylation; Acetic anhydride; Kinetics; Hydrolysis; Efficiency
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Fonds Quebecois de la Recherche sur la Nature et les Technologies (FQRNT)
Chitosan reacetylation kinetics and efficiency were studied in water-methanol (MeOH) mixtures. The polymer was dissolved using acetic acid and acetic anhydride was used for reacetylation. Combining second-order kinetics and acid-base dissociation equations of chitosan, and using acetic anhydride hydrolysis rates determined by conductivity measurements, reacetylation reaction rate constants of 187, 108,46 min(-1) M(-1) were found in 0.50 and 80% MeOH (v/v), respectively. Contrary to previous literature, it was found that improvement in reacetylation efficiency in the presence of MeOH is mainly due to an increase of acetic acid pK(a) by MeOH that limits the ionization of the polymer in the course of the reaction rather than to a decreased acetic anhydride hydrolysis rate, as previously thought. Based on these insights, the model developed in this study was able to predict the significantly reduced efficiency of the reaction for a large extent of reacetylation, without requiring any steric hindrance from the acetyl group. Conditions to maximize the reaction efficiency for a large extent of reacetylation were identified. (C) 2011 Elsevier Ltd. All rights reserved.
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