期刊
CARBOHYDRATE POLYMERS
卷 90, 期 3, 页码 1362-1370出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.07.005
关键词
Nonwoven; Wound healing; Silver; Gellan; Hyaff (R)
Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff (R) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa. (C) 2012 Elsevier Ltd. All rights reserved.
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