期刊
CARBOHYDRATE POLYMERS
卷 89, 期 4, 页码 1101-1109出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.03.073
关键词
Adjuvant; LPS; Cancer; Immunotherapy; bFGF; Hydrogel
资金
- National Major Project [2009ZX09503-005]
- National Science Foundation of China [30973453]
- Scientific Research Foundation for Young Teachers of Sichuan University
The need to enhance the immunogenicity of tumor-associated antigens and modulate the resulting immune responses has prompted the development of new adjuvants. We prepared a novel adjuvant, lipopolysaccharides (LPS) loaded thermosensitive hydrogel (LPS-Hydrogel), for truncated basic fibroblast growth factor (tbFGF) peptide to enhance immunological responses and improve therapeutic effects in cancer. When co-formulated with tbFGF, LPS-Hydrogel formed antigen-adjuvant complexes, which enhanced antibody and cell-mediated responses in mice, thus promoting a more balanced antibody-mediated and cytotoxic T lymphocyte (CTL)-mediated immune response to inhibit tumor growth and metastases in vivo. Furthermore, the secretion of IFN-gamma and IL-4 was detected, confirming activation of the two immune responses in vivo. There were no significant systemic toxicities observed with tbFGF-LPS-Hydrogel treatment. These results suggested that the thermosensitive and biodegradable LPS-Hydrogel was a novel adjuvant and carrier for peptide vaccines in cancer immunotherapy. (C) 2012 Elsevier Ltd. All rights reserved.
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