期刊
CARBOHYDRATE POLYMERS
卷 89, 期 2, 页码 709-712出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.03.081
关键词
Native hyaluronic acid; Low-molecular-weight hyaluronic acid; Ozone; Degradation
资金
- Binzhou University [2009ZDL04, 2009Y03]
Recently, low-molecular-weight hyaluronic acid has been reported to have novel features, such as free radical scavenging activities, antioxidant activities, promotion of excisional wound healing, etc. In the present work, degradation of native hyaluronic acid by ozone treatment was performed for preparation of low-molecular-weight hyaluronic acid. The molecular weight of native hyaluronic acid was reduced from 1535 to 87 kDa for 120 min at 40 degrees C. The rate of reduction of molecular weight was 94.33%. The FT-IR, C-13 NMR, and UV-vis spectra suggested that there was no obvious modification of chemical structure of low-molecular-weight hyaluronic acid. The use of degradation of native hyaluronic acid by ozone treatment can be a useful alternative for production of low-molecular-weight hyaluronic acid. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据