期刊
NEUROMOLECULAR MEDICINE
卷 7, 期 3, 页码 255-264出版社
HUMANA PRESS INC
DOI: 10.1385/NMM:7:3:255
关键词
dementia; lymphocyte; leukocyte; aging; brain; amyloid
Alzheimer's disease (AD) is the most common dementing illness and is pathologically characterized by deposition of the 40-42 amino acid peptide, amyloid-beta (A beta), as senile plaques. It is well documented that brain inflammatory mechanisms mediated by reactive glia are activated in response to A beta plaques. A number of reports further suggest that T-cells are activated in AD patients, and that these cells exist both in the periphery and as infiltrates in the brain. We explore the potential role of T-cells in the AD process, a controversial area, by reviewing reports that show disturbed activation profiles and/or altered numbers of various subsets of T-cells in the circulation as well as in the AD brain parenchyma and in cerebral amyloid angiopathy. We also discuss the recent A beta immunotherapy approach vis-a-vis the activated, autoaggressive T-cell infiltrates that contributed to aseptic meningoencephalitis in a small percentage of patients, and present possible alternative approaches that may be both efficacious and safe. Finally, we explore the use of mouse models of AD as a system within which to definitively test the possible contribution of T-cells to AD pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据