期刊
CARBOHYDRATE POLYMERS
卷 90, 期 1, 页码 431-440出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.05.062
关键词
Chondroitin sulfate; Biomimetic; Proteoglycan; H-1 NMR; Bottle brush polymer synthesis
资金
- Coulter Foundation
Chondroitin sulfate (CS) based bottle brush proteoglycan mimetics may be employed to restore tissue functionality. Synthesis of CS bottle brush structures requires immobilization of CS at its terminal end. In this study, we investigated commercially available natural CS for use in CS bottle brush synthesis. A terminal primary amine on CS was identified and utilized to conjugate amine-reactive vinyl monomers (i.e. acrylic acid and allyl glycidyl ether). Conjugation of vinyl monomers to the CS terminal amine was confirmed using a fluorescamine assay, H-1 NMR, and ATR-FTIR. CS was also immobilized onto epoxy functionalized surfaces via the CS terminal primary amine as confirmed by contact angle measurements of surface wettability. Attachment of polymeriziable end groups to CS and attachment of CS to functionalized substrates demonstrated here are the first steps towards synthesis of CS bottle brush PG mimics. (C) 2012 Elsevier Ltd. All rights reserved.
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