期刊
SPECTROSCOPY-AN INTERNATIONAL JOURNAL
卷 19, 期 5-6, 页码 259-266出版社
IOS PRESS
DOI: 10.1155/2005/258617
关键词
hypocrellin B; MCHB; CT-DNA; intercalation mechanism; circular dichroism spectroscopy; fluorescence spectroscopy; anticancer drugs
The interaction of anticancer drug hypocrellin B (HB) and mono-cysteine substituted hypocrellin B (MCHB) with calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra showed that the HB and MCHB can intercalate into the base-stacking domain of the CT-DNA double helix. Further studies based on fluorescence spectroscopy and circular dichroism (CD) spectroscopy also supported the intercalation mechanism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据