期刊
CARBOHYDRATE POLYMERS
卷 88, 期 2, 页码 663-669出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.01.020
关键词
Sodium alginate derivative; Disulfide cross-linked nanospheres; pH-sensitivity; Reduction-response; Colon-specific drug delivery
资金
- Wuhan University of Technology [ZY-HG-010]
- National University Student Innovation Test plan of Wuhan University of Technology [091049772]
- Natural Science Foundation of China [50973088]
Reducible sodium alginate nanospheres cross-linked with disulfide linkages were developed for site-specific drug delivery in inflammatory bowel disease. The nanospheres were synthesized by self-assembly of amphiphilic thiolated sodium alginate (TSA) in deionized water and subsequently producing disulfide bond cross-linking. TEM showed that the nanospheres had a spherical core-shell configuration with a size of about 170 nm. Dynamic light scattering showed that the nanospheres had high stability, narrow size distribution and a pH-dependent swelling transition. Cytotoxicity study indicated that the nanospheres had no apparent cell inhibition. Moreover, the size of the nanospheres increased because of the cleavage of disulfides within their network structures in 10 mM glutathione (GSH) solution. As compared with-that in GSH-free buffer, the drug release in pH 6.0 buffer with GSH from drug-loaded nanospheres exhibited a marked increase, indicating that the nanospheres may be used for colon-specific drug delivery. (c) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据