期刊
CARBOHYDRATE POLYMERS
卷 90, 期 4, 页码 1664-1670出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.07.047
关键词
Apostichopus japonicus; Polysaccharide; Antioxidant activity; Antihyperlipidemic activity
资金
- National Natural Science Foundation of China [31000008]
- Science and Technology Program of Shandong Province [BS2010HZ019, BS2009HZ004, 2012GGA10045]
- Key Laboratory of Marine Drug (Ocean University of China), Ministry of Education
Polysaccharides (AJP) were prepared from Apostichopus japonicus by protease hydrolysis method. Antioxidant activity in vitro and antihyperlipidemic activity in vivo was investigated. Chemical composition analysis indicated that AJP was mainly composed of glucosamine, galactosamine, glucuronic acid, mannose, glucose, galactose and fucose, with an average molecular weight of about 36.2 kDa. The antioxidant capacities of AJP were, respectively, evaluated by the assays of scavenging DPPH, hydroxyl and superoxide radicals, and reducing power in vitro. It showed potent free radical scavenging activities and reducing power. Serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL-C) decreased significantly and high-density lipoprotein cholesterol (HDL-C) increased significantly after treatment of hyperlipidemic Wistar rats with AJP. These results suggest that AJP may prove to be a potential candidate of the natural antioxidants as a therapeutic agent for hyperlipidemia. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据