期刊
CARBOHYDRATE POLYMERS
卷 88, 期 3, 页码 1072-1076出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.01.068
关键词
Cordyceps gunnii; High-molecular-weight polysaccharide; Characteristic; Antitumor
资金
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1166]
- National Agricultural Innovation Project [2011GB2A100009]
- Natural Science Foundation of Tianjin City [09JCZDJC21800, 09JCYBJC15800]
- Foundation of Tianjin Educational Committee [20090604]
- National Natural Science Foundation of China (NSFC) [31170541]
- Program for New Century Excellent Talents in University [NCET-10-0951]
Cordyceps gunnii (berk.) Berk (C. Gunnii) is well known as a Chinese rare caterpillar fungus and has similar pharmacological activity with C. sinensis. In this work, a high-molecular-weight polysaccharide (CPS) was isolated and purified from the mycelia of C. gunnii. The total sugar content of CPS was amounted to 92.84%. The result of HPLC indicated that CPS was a homogeneous polysaccharide. The estimated average molecular weight of CPS was 3.72 x 10(6) Da. The specific rotation of CPS was recorded [alpha](D)(25) = +134.2 degrees. Its characteristic was determined by chemical analysis, gas chromatography, IR spectroscopy and NMR data. The results showed that CPS was mainly composed of glucose, and a small amount of rhamnose, arabinose, xylose, mannose and galactose with a molar ratio of Rha:Ara:Xyl:Man:Glu:Gal = 3.0:2.6:1.0:1.3:106.0:2.8. The main chain of CPS was majorly composed of alpha-(1 -> 4) glucose. The tumor inhibition ratio on K562 cell by CPS was 56.65%. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据