期刊
CARBOHYDRATE POLYMERS
卷 84, 期 1, 页码 533-538出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.12.017
关键词
Antimicrobial wound dressing; Bacterial cellulose; Benzalkonium chloride; Dry film
资金
- Science and Technology Commission of Shanghai Municipality [0852nm03500, 08520750200]
- Shanghai Municipal Education Commission [09ZZ68]
- Fundamental Research Funds for the Central Universities
- Key Laboratory of Textile Science & Technology (Donghua University) of Ministry of Education of China
- 111 Project [B07024]
A kind of antibacterial bacterial cellulose (BC) dry film was developed and characterized as a potential functional wound dressing for acute traumas treatment. To achieve this, a freeze-dried BC film was immersed in a benzalkonium chloride solution, which belongs to cationic surfactant type antimicrobial agent, followed by another freeze-drying step. Some physical and antimicrobial properties of the prepared BC films were investigated and the results showed that the drug-loading capacity of the BC dry film was about 0.116 mg/cm(2) when soaked in 0.102% benzalkonium chloride solution. High water absorbing capacity, an important quality for wound dressings was also achieved with a swelling ratio of 26.2 in deionized water and of 37.3 in saline solution. With respect to the antimicrobial effect, a stable and prolonged antimicrobial activity for at least 24 h was obtained especially against Staphylococcus aureus and Bacillus subtilis, which were general Gram-positive bacteria that found on the contaminated wound. (C) 2010 Elsevier Ltd. All rights reserved.
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