We investigated the relevance of p53 deletions to the clinical outcome of patients with multiple myeloma (MM) treated with high-dose chemotherapy and autologous stem cell transplantation. Hemizygous p53 gene deletions were detected by fluorescence in situ hybridization in 10 of 105 (9.5%) patients studied. p53 deletions were associated with higher serum calcium (P =.0062) and creatinine (P =.013) levels, but there were no association with patient age, gender, beta(2)-microglobulin, C-reactive protein, hemoglobin, albumin or bone lytic lesions, or immunoglobulin isotype. There were no associations of p53 deletions with 13q deletions or translocations t(11;14) or t(4;14). Patients with p53 deletions had significantly shorter progression-free (median, 7.9 versus 25.7 months, P =.0324) and overall survival (median, 14.7 versus 48.1 months, P =.0008) than patients without a p53 deletion. A multivariate analysis confirmed p53 deletion was an independent prognostic factor predicting shortened progression-free (P =.0009) or overall survival (P =.0002) in patients with MM after high-dose chemotherapy and autologous stem cell transplantation. (C) 2005 by The American Society of Hematology.
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