期刊
CARBOHYDRATE POLYMERS
卷 83, 期 3, 页码 1303-1310出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.09.041
关键词
Hyaluronic acid; Nanoemulsion; Fluorescence; Stability; Encapsulation efficiency
资金
- Ministry of Health and Welfare, Republic of Korea [A050376]
- Korea Health Promotion Institute [A050376] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, stability of hyaluronic acid (HA) based nanoemulsion was systematically investigated. Factors including zeta potential, pH, crosslinking agents and degree of substitution (DS) were considered to assess their roles in stability. Nanoemulsions prepared from HA-GMS with higher DS showed smaller droplet sizes. In the presence of Ca2+ as a crosslinker, size distribution was improved to be more uniform at the expense of size increases within a controllable range. The optimal amount of Ca2+ usage was determined as 0.05%, which alleviated droplet flocculation and improved morphological qualities as well. Electrostatic, steric, and hydrophobic effects were verified to play crucial roles in emulsion stability. Surfactants strategy was another prerequisite making a key contribution. Encapsulation efficiency (E.E.) study using vitamin E as a model active ingredient proved the eligibility of HA-GMS nanoemulsion exploited as carriers, where the highest E.E. was 93.9 +/- 1.4% occurring in sample L6. Fluorescence quenching assay offered evidence of VE encapsulation inside the hydrophobic interior of HA-GMS nanodroplets. (C) 2010 Elsevier Ltd. All rights reserved.
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