Effects and mechanism of low molecular weight fucoidan in mitigating the peroxidative and renal damage induced by adenine

In the present study, the beneficial effects of two sulfated polysaccharides DF and UF on adenine-induced chronic kidney disease (CKD) were investigated. Compare the chemical composition of DF and UF, DF had more sulfated group than OF, however, UF had more uronic acid. The results showed OF and OF had significant protective role in deleting the peroxidative and renal damage in CKD rats. Both samples exhibited nearly the same effect on the SUN and SCR level, however, OF showed greater effect on activity/level of CAT, GSH-PX, GSH and MDA in serum and liver compared to UF. That was to say the sample with higher content of sulfate group exhibited greater antioxidant activity. There was a positive correlation between MDA level and renal membrane damage indicating a striking relation between free radical formation and cellular injury. The mechanism of OF and OF on the CKD rats had relationship with their antioxidant activities, the samples which could enhance the activity of antioxidant enzymes and reduce the LPO level could alleviate the symptom of CKD complications. (C) 2010 Elsevier Ltd. All rights reserved.