期刊
CARBOHYDRATE POLYMERS
卷 84, 期 2, 页码 794-802出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.04.035
关键词
Chitosan; Gallic acid; Radical scavenging; PH-responsive
A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH center dot and ABTS(+) radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future. (C) 2010 Elsevier Ltd. All rights reserved.
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