期刊
CARBOHYDRATE POLYMERS
卷 81, 期 1, 页码 1-7出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.01.040
关键词
Dendrobium nobile Lindl; Acidic polysaccharide; Structure; Immunological activity
资金
- National Natural Science Foundation of China [20872024]
- International Foundation for Science [F/4577-1]
- Ministry of Education of China [109091]
- Key Project for the Outstanding Young Researchers in Higher School of Anhui Province of China [2009SQRZ016ZD]
Dendrobium nobile is commonly used as a Yin tonic for reinforcing body fluid and nourishing blood in Southeast Asia. In this paper, a pectic polysaccharide DNP-W5 was obtained from the stems of D. nobile. It contained mannose, glucose, galactose, xylose, rhamnose and galacturonic acid in molar ratios of 3.1:8.1:8.2:0.6:4.2:3.9. About 21% of the galacturonic acid existed as methyl ester and O-acetyl groups were approximately 6.9%. The structural analysis indicated that DNP-W5 possessed a backbone of a disaccharide of [-> 4)-alpha-GalAp-(1 -> 2)-alpha-Rhap-(1 ->] with branches at O-4 of the Rhap and O-3 of the GalpA. The side chains consisted of galactosyl, mannosyl, glucosyl, and xylosyl residues. In vitro bioactive tests, DNP-W5 displayed remarkable immunoenhancing activities on T- and B-lymphocytes and its branches and acetyl groups are very important for the expression of the immunological activity. (C) 2010 Published by Elsevier Ltd.
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