期刊
CARBOHYDRATE POLYMERS
卷 79, 期 1, 页码 114-118出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.07.032
关键词
Dendrobium nobile Lindl; Polysaccharides; Antitumor activities
资金
- International Foundation for Science
- Organisation for the Prohibition of Chemical Weapons [F/4577-1]
- National Natural Science Foundation of China [20872024]
- Ministry of Education of China [109091]
- Key Project for the Outstanding Young Researchers in Higher School of Anhui Province of China [2009SQRZ016ZD]
- Foundation of Hefei University of Technology for Young Teacher [073001 F]
The antitumor activities of extracted polysaccharide fractions from the stems of Dendrobium nobile Lindl were investigated. Polysaccharides were sequentially extracted from the stems of D. nobile to obtain three fractions, i.e. water extract fraction (DNP-W), 5% NaOH extract fraction (DNP-OH) and 5% HCl extract fraction (DNP-H). Further the DNP-W was isolated to give six sub-fractions (DNP-W1, DNP-W2, DNP-W3, DNP-W4, DNP-W5 and DNP-W6) by anion-exchange chromatography. The monosaccharide profile, protein content, uronic acid content, total carbohydrate content, viscosity and molecular weight of nine polysaccharide fractions were analyzed. Both the in vivo and in vitro antitumor activities of nine polysaccharide fractions were evaluated and compared. Results indicated that DNP-W1 and DNP-W3 exhibited high antitumor activities against Sarcoma 180 in vivo and HL-60 in vitro. The results suggested that DNP-W1 and DNP-W3 could be considered as an effective natural antitumor source. (C) 2009 Elsevier Ltd. All rights reserved.
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