4.7 Article

Comparison of the immunological activities of arabinoxylans from wheat bran with alkali and xylanase-aided extraction

期刊

CARBOHYDRATE POLYMERS
卷 81, 期 4, 页码 784-789

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ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.03.040

关键词

Wheat bran arabinoxylan; Alkaline extraction; Enzyme extraction; Immunomodulators

资金

  1. State-level Public Welfare Scientific Research Institutes of the Chinese Academy of Agriculture Sciences
  2. Comprehensive Technology Platform of New Drug Research of the Ministry of Science and Technology [2009ZX09301-003]

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Differences in immunoregulatory activities of arabinoxylans (AXs) from wheat bran extracted by alkaline- and enzyme-based methods are unknown. We extracted AX from wheat bran by the 2 procedures. Chemical analysis revealed that alkaline-extracted AX (AX(A)) contained a lower amount of protein (4.10%) than enzyme-extracted AX (AX(E), 9.85%) and no ferulic acid (as compared with 43.5 mg/100 g in AX(E)). AX(A) consisted of a highly substituted population with a ratio of arabinose to xylose of 0.83 (AX(E): 0.56), meanwhile the weight-average molecular weight of AX(A) (3.517 x 10(5) Da) was about 10 times that of AX(E) (3.252 x 10(4) Da). Both AX(A) and AX(E) had potent stimulating effects on innate and acquired immune responses on oral administration in female BALB/c mice. AX(E) showed higher macrophage phagocytosis and delayed hypersensitivity reaction than did AX(A), with no significant differences in enhancing lymphocyte proliferation. Whether extracted by alkaline- or enzyme-aided methods, the obtained AXs could be explored as potent natural immunomodulators. (C) 2010 Elsevier Ltd. All rights reserved.

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