期刊
CARBOHYDRATE POLYMERS
卷 81, 期 3, 页码 607-611出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.03.020
关键词
Exopolysaccharide; Enterobacter cloacae; Immunomodulation; Antioxidant
资金
- National Key Technology R&D Program, China [2006BAD14B06-4]
- Science and Technology Key Program of Zhejiang Province, China [2007C12041]
A water-soluble extracellular polysaccharide (EPS-1) was isolated from the submerged culture broth of Enterobacter cloacae Z0206 through fermentation, ethanol precipitation, anion-exchange and gel-permeation chromatography. Its structural analysis showed that the average molecular weight of EPS-1 was 23,928 Da, and it was composed of glucose, mannose and galactose with a molar ratio of 6.860:1.180:0.455. It was hypothesized that EPS-1 belongs to the alpha-type heteropolysaccharide with pyran group. Bioactivity tests in vivo showed that the administration of EPS-1 to cyclophosphamide (CP)-exposed animals resulted in significant increase and recovery of B lymphocyte proliferation, tumor necrosis factor alpha (TNF-alpha) production and activities of antioxidant enzymes (superoxide dismutase (SOD) and glutathione peroxidase (GPx)). It is suggested that EPS-1 could provide protection against CP-induced immunosuppression and oxidative damage in mice model, and it may act as a potent immunomodulatory and antioxidant agent. (C) 2010 Elsevier Ltd. All rights reserved.
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