期刊
CARBOHYDRATE POLYMERS
卷 77, 期 4, 页码 839-844出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.03.006
关键词
Chitosan; Poly(3-hydroxybutyrate); Microparticles; Controlled drug release
Poly(3-hydroxybutyrate)/chitosan/piroxicam or ketoprofen composite microparticles were prepared by the solid-in-water-in-oil emulsion-solvent evaporation technique with the aim of reducing the burst effect and controlling the drug release. Reservoir-type microparticles, composed of poly(3-hydroxybutyrate) microspheres embedded in a chitosan matrix were prepared. The size and morphological characteristics of the composite microparticles were evaluated in relation to the chitosan concentration and crosslinking with glutaraldehyde. Reservoir-type composite microparticles were obtained using 2.0% and 3.0% w/v chitosan solutions. A significant reduction in the burst effect and prolonged drug release were observed, particularly when higher chitosan and glutaraldehyde concentrations were used. (C) 2009 Elsevier Ltd. All rights reserved.
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