期刊
FASEB JOURNAL
卷 19, 期 1, 页码 659-+出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.04-3182fje
关键词
AD; A beta neuropathology; neuritic plaque deposition
资金
- NATIONAL INSTITUTE ON AGING [P01AG002219] Funding Source: NIH RePORTER
- NIA NIH HHS [AG02219] Funding Source: Medline
This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing beta-amyloid (Abeta) neuropathology pivotal to the initiation and progression of the disease. We report that a CR dietary regimen prevents Abeta peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti-amyloidogenic alpha-secretase activity. Study findings support existing epidemiological evidence indicating that caloric intake may influence risk for AD and raises the possibility that CR may be used in preventative measures aimed at delaying the onset of AD amyloid neuropathology.
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