期刊
CARBOHYDRATE POLYMERS
卷 73, 期 4, 页码 582-586出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2007.12.025
关键词
chitosan; rosin-(2-acryloy loxy)ethyl ester; graft copolymer; microwave; drug release
Graft copolymerization of rosin-(2-acryloyloxy)ethyl ester (RAEE) onto chitosan (Cts) was carried out under microwave irradiation using potassium persulfate as an initiator. The structures, morphology, and thermal properties of the Cts graft copolymer (Cts-g-PRAEE) were characterized by means of FT-IR, XRD, SEM, and TG. Also, Cts and Cts-g-PRAEE copolymer were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice were studied. The results show that the rate of release of fenoprofen calcium from the carrier of Cts-g-PRAEE copolymer becomes very slower than that of Cts in artificial intestinal juice. (C) 2008 Published by Elsevier Ltd.
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