期刊
FEBS JOURNAL
卷 272, 期 18, 页码 4607-4616出版社
WILEY
DOI: 10.1111/j.1742-4658.2005.04862.x
关键词
Sir2; deacetylation; sirtuin; NAD; sirtinol; splitomicin; resveratrol
资金
- NIGMS NIH HHS [GM065386] Funding Source: Medline
- PHS HHS [5 T32 G08349] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065386] Funding Source: NIH RePORTER
The Sir2 family of histone/protein deacetylases (sirtuins) is comprised of homologues found across all kingdoms of life. These enzymes catalyse a unique reaction in which NAD(+) and acetylated substrate are converted into deacetylated product, nicotinamide, and a novel metabolite O-acetyl ADP-ribose. Although the catalytic mechanism is well conserved across Sir2 family members, sirtuins display differential specificity toward acetylated substrates, which translates into an expanding range of physiological functions. These roles include control of gene expression, cell cycle regulation, apoptosis, metabolism and ageing. The dependence of sirtuin activity on NAD(+) has spearheaded investigations into how these enzymes respond to metabolic signals, such as caloric restriction. In addition, NAD(+) metabolites and NAD(+) salvage pathway enzymes regulate sirtuin activity, supporting a link between deacetylation of target proteins and metabolic pathways. Apart from physiological regulators, forward chemical genetics and high-throughput activity screening has been used to identify sirtuin inhibitors and activators. This review focuses on small molecule regulators that control the activity and functions of this unusual family of protein deacetylases.
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