期刊
CANCER TREATMENT REVIEWS
卷 40, 期 1, 页码 12-21出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2013.08.003
关键词
Primary cilia; Stroma; MDSCs; Gli1; Stomach
类别
资金
- NIDDK NIH HHS [P01 DK062041] Funding Source: Medline
This review summarizes emerging information regarding the Hedgehog (Hh) signaling pathway during neoplastic transformation in the gastrointestinal tract. Although there is a role for the well-established canonical pathway in which Hedgehog ligands interact with their receptor Patched, there is sufficient evidence that downstream components of the Hh pathway, e.g., Glil, are hijacked by non-Hh signaling pathways to promote the conversion of the epithelium to dysplasia and carcinoma. We review the canonical pathway and involvement of primary cilia, and then focus on current evidence for Hh signaling in luminal bowel cancers as well as accessory organs, i.e., liver, pancreas and biliary ducts. We conclude that targeting the Hh pathway with small molecules, nutriceuticals and other mechanisms will likely require a combination of inhibitors that target Gli transcription factors in addition to canonical modulators such as Smoothened. (C) 2013 Elsevier Ltd. All rights reserved.
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