期刊
CANCER TREATMENT REVIEWS
卷 40, 期 2, 页码 293-299出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2013.09.010
关键词
Breast cancer; Metastasis; Gene expression; Tumor stroma; Polymorphism; Genetic background
类别
The crucial event in the course of malignancies such as breast cancer is its metastatic spread from the primary tumor of origin to distant organs. The natural history of a tumor is determined by the expression of its genes, and in this sense, knowledge has advanced dramatically in recent decades. However, much less is known about the role that the patient plays in the behavior of a tumor. In this article, we review the evidence regarding the genetic background of the host in metastatic tumor dissemination, providing information from epidemiological studies as well as from animal models and human studies. Undoubtedly, the elucidation of possible interpersonal variability in susceptibility to developing metastases would significantly contribute to improve management of cancer patients. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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