期刊
CANCER TREATMENT REVIEWS
卷 38, 期 3, 页码 218-225出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2011.06.010
关键词
HCC; Tumor microenvironment; ECM; Hypoxia; Molecular target; Anti-cancer therapy
类别
资金
- National Basic Research Program of China [2007CB936000]
- Ministry of Health [2009ZX10004-301]
- China National Key Projects for Infectious Diseases [2008ZX10002-017]
- National Nature Science Foundation of China [30772505, 30872503]
Hepatocellular carcinoma (HCC) is the most common form of liver cancer throughout the world. The microenvironment of the HCC is composed of non-tumor cells and their stroma, with the stroma having been implicated in the regulation of tumor growth, metastatic potential and outcome following therapy. Thus, the tumor microenvironment has become an important target for HCC treatment. In this review article, we will discuss the cellular and molecular components of the hepatoma microenvironment, effects on tumor development and progression, the relationship to prognosis, and the implications for targeting of this microenvironment in the control of HCC. (C) 2011 Elsevier Ltd. All rights reserved.
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