期刊
CANCER TREATMENT REVIEWS
卷 37, 期 7, 页码 567-578出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2011.04.004
关键词
Stereotactic; Radiosurgery; Radiation therapy; Necrosis; Cranial neuropathies
类别
Single-fraction stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (SRT) are radiation planning and delivery techniques used for the treatment of intracranial and spine/spinal cord tumors and targets. For cranial SRS and SRI, critical normal tissues/structures include the brainstem, cranial nerves, cochlea and normal brain parenchyma. For spine SRS/SRT, critical normal tissues/structures include the spinal cord, cauda equina as well as neighboring organs. This paper reviews clinical studies investigating central nervous system dose tolerances after cranial or spinal SRS/SRT. The impact of dose, volume, fractionation, and other relevant clinic-pathologic variables are discussed, as are limitations of the published data. (C) 2011 Elsevier Ltd. All rights reserved.
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