期刊
EUROPEAN HEART JOURNAL
卷 26, 期 2, 页码 145-152出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehi021
关键词
ACE-inhibitors; myocardial infarction; mortality; morbidity; follow-up; prognosis
Aims To investigate the long-term benefits of treatment with angiotensin-converting enzyme (ACE)-inhibitors in patients with myocardial infarction (MI) and left ventricular dysfunction (120). Methods and results In the trandolapril cardiac evaluation (TRACE) study, 1749 patients with LVD (ejection fraction <= 35 %) were randomized to trandolapril (n = 876) or placebo (n = 873) 3-7 days post-MI. Enrolment lasted from 1990 to 1994; on-treatment follow-up ranged from 2 to 4 years. At study closure, all patients were recommended continued ACE-inhibitor use. National registries were used to track deaths and hospitalizations until 2002. Mortality was analysed with Cox proportional hazard models and hospitalization with Poisson regression models (models adjusted for observation time). Over 10-12 years of follow-up, a total of 1283 deaths and 9220 hospitalizations were registered. Compared with the placebo group, the trandolapril group had a significantly reduced risk of all-cause mortality (relative risk 0.89, 95 % Cl 0.80-0.99, P = 0.03), all-cause hospitalizations (rate ratio 0.92, 95 % CI 0.88-0.96, P < 0.001), and cardiovascular hospitalizations (rate ratio 0.95, 95 % Cl 0.91-1.00, P = 0.047), including congestive heart failure hospitalizations (rate ratio 0.85, 95 % Cl 0.77-0.93, P < 0.001). Conclusion In patients with LVD, use of trandolapril shortly after an MI for 2-4 years has tong-term benefits. The beneficial effect on mortality and hospitalization rates is maintained for at least 10-12 years.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据