期刊
CANCER TREATMENT REVIEWS
卷 36, 期 2, 页码 151-156出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2009.11.006
关键词
FoxM1; Cancer; Cell signaling pathway; Chemopreventive agents
类别
资金
- National Cancer Institute, NIH [1 R01CA132794]
- NATIONAL CANCER INSTITUTE [R01CA131151, R01CA132794, R01CA101870] Funding Source: NIH RePORTER
FoxM1 signaling has been reported to be associated with carcinogenesis. Therefore, the FoxM1 may represent a novel therapeutic target, and thus the development of agents that will target FoxM1 is likely to have significant therapeutic impact on human cancer. This review describes the mechanisms of signal transduction associated with FoxM1 and provides emerging evidence in support of its role in the carcinogenesis. Further, we summarize data on several FoxM1 inhibitors especially chemopreventive agents and these agents could be useful for targeted inactivation of FoxM1, which indeed could become a novel approach for the prevention and/or treatment of human cancer. (C) 2009 Elsevier Ltd. All rights reserved.
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