期刊
CANCER TREATMENT REVIEWS
卷 34, 期 1, 页码 13-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2007.07.017
关键词
radiolabeled peptides; tumor imaging; radiotherapy; somatostatin; bombesin; cytotoxic peptide
类别
A hope for the diagnosis and treatment of cancer is the development of new tumorspecific peptide-based radiopharmaceuticals. The overexpression of many peptide receptors on human tumors makes such receptors an attractive potential target for diagnostic imaging and radiotherapy with specifically designed radiolabeled peptides. The use of solid-phase peptide synthesis, and the availabitity of a wide range of bifunctional chelating agents for the convenient radiolabeling of bioactive peptides with different radionuclides have produced a wide variety of medicinally useful peptide radiopharmaceuticals. A few of these peptides, such as somatostatin, bombesin, cholecystokinin/gastrin, neurotensin and vasoactive intestinal peptide are currently under investigation for their possible clinical. applications in nuclear oncology. This article presents the recent development in radiolabeled small peptides, with major emphasis on somatostatin and bombesin analogs. (c) 2007 Elsevier Ltd. All rights reserved.
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