期刊
CANCER SCIENCE
卷 105, 期 8, 页码 956-965出版社
WILEY
DOI: 10.1111/cas.12463
关键词
Gallbladder cancer; MiR-135a; p38; proliferation; very low density lipoprotein receptor
类别
资金
- Science and Technology Commission of Shanghai Municipality [11nm0503900, 12nm0501502, 12QA1403100]
- Shanghai Municipal Commission of Health and Family Planning [XYQ2011042]
The precise functions and mechanisms of microRNAs (miR) in gallbladder cancer (GBC) remain elusive. In this study, we found that miR-135a-5p expression is often dampened and correlated with neoplasm histologic grade in GBC. MicroRNA-135a-5p introduction clearly inhibited GBC cell proliferation in vitro and in vivo. Moreover, very low density lipoprotein receptor (VLDLR), which is often upregulated in GBC tissues, was identified as a direct functional target of miR-135a-5p. Furthermore, the p38 MAPK pathway was proven to be involved in miR-135a-VLDLR downstream signaling. Together, these results suggested that the miR-135a-VLDLR-p38 axis may contribute to GBC cell proliferation.
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