期刊
CANCER SCIENCE
卷 105, 期 11, 页码 1447-1456出版社
WILEY
DOI: 10.1111/cas.12531
关键词
Gastric cancer; overall survival; predictive nomogram; prognostic biomarker; stromal cell-derived factor 1
类别
资金
- National Key Projects for Infectious Diseases of China [2012ZX10002-012]
- National Natural Science Foundation of China [31100629, 31270863, 31300671, 31470794, 81471621, 81472227]
- Program for New Century Excellent Talents in University [NCET-13-0146]
- Shanghai Rising-Star Program [13QA1400300]
- Key Project of Science and Technology Commission of Shanghai Municipality [09DZ1950101, 11411951000, 12140902000]
- Research Fund for Excellent Doctor of Shanghai Medical College of Fudan University [EZF152309]
Aberrant chemokine stromal cell-derived factor 1 (SDF-1) expression has been shown to be involved in the development and progression of various malignancies. Our present study aims to investigate the clinical and prognostic value of SDF-1 expression and improve risk stratification in patients with gastric cancer. Peritumoral and intratumoral SDF-1 levels were assessed in 220 retrospectively enrolled gastric cancer patients, and their relations with clinicopathological features and clinical outcomes were evaluated. A predictive nomogram was created to refine risk stratification for overall survival of gastric cancer patients. Compared with peritumor tissues, tumor tissues showed decreased SDF-1 expression levels according to TNM stage progression in gastric cancer specimens. Peritumoral SDF-1 expression correlated positively with tumor invasion depth and lymph node metastasis, whereas intratumoral SDF-1 expression associated negatively with tumor size, tumor differentiation, tumor invasion depth, lymph node metastasis, and clinical TNM stage. Moreover, both low peritumoral SDF-1 expression and high intratumoral SDF-1 expression indicated favorable overall survival, and SDF-1 risk derived from the peritumoral/intratumoral SDF-1 expression signature could stratify prognosis of patients with gastric cancer. After backward elimination, SDF-1 risk was identified as an independent prognostic factor for survival. Finally, a predictive nomogram was generated with identified independent prognosticators to assess patient survival at 3 and 5years following surgery. Conclusively, SDF-1 risk, an identified independent prognostic factor, could be developed into a nomogram with tumor invasion depth, lymph node involvement, and distant metastasis to refine predictive accuracy for survival in patients with gastric cancer after surgical resection.
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