期刊
CANCER SCIENCE
卷 104, 期 9, 页码 1217-1225出版社
WILEY
DOI: 10.1111/cas.12202
关键词
-
类别
资金
- CA [127535]
- CDMRP [W81XWH-05-1-0091, W81XWH-05-1-0318]
- NIH [T32 CA075924]
- National Natural Science Foundation of China [30971137, 31171308, 81172208]
- Shanghai Advanced Research Institute, Chinese Academy of Sciences [1105022000]
- Shanghai Committee of Science and Technology [13XD1402600]
Tumor-associated macrophages (TAM) play a critical role in promoting tumor development and metastasis. In the present study, we found that legumain, an asparaginyl endopeptidase, was highly expressed on the surface of TAM. A doxorubicin-based prodrug specifically activated by legumain selectively ablated TAM and resulted in a significant reduction of angiogenic factors and related tumor vessel growth. Treatment with the prodrug also suppressed circulating tumor cells and myeloid immune suppressor Gr-1+/CD11b+ cells in tumor-bearing animals. After selective ablation of TAM using the prodrug, tumor growth and metastases were greatly inhibited in murine tumor models. These results indicate that legumain-activated prodrugs targeting TAM in tumors might represent a novel anticancer strategy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据