期刊
出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10934529.2015.975042
关键词
Candida albicans yeasts and biofilm; thymoquinone; nanodrugs; ketoconazole; Amphotericin-B
资金
- Deanship of Research, University of Dammam, Dammam, Saudi Arabia [2011023]
- KFUPM [R15-CW-11 (MIT13104/13105)]
In the current study, nano-particulated drugs-Amphotericin-B, Ketoconazole and Thymoquinone (an active ingredient of Nigella sativa)-were prepared using the ball milling technique, and their particle sizes were examined by transmission electron microscopy (TEM) and using a particle size analyzer. The grain sizes of the prepared compounds were found in between 5 to 20nm, and exhibited quasi-spherical morphology. The antifungal activity of each nano-particulated drug was investigated in vitro against Candida albicans yeasts and Candida biofilm, and compared with their micro-structured conventional forms. Nano-sized drugs were found to be two to four times more effective in disinfecting both the Candida yeasts and Candida biofilm. The study is a first of its kind as nano-forms of drugs have not been studied against Candida and Candida biofilm before. Further investigations are required for the determination of the clinical significance of the nano-formulation of antifungal substances.
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