4.8 Article

Efficient Pd-catalyzed amination of heteroaryl halides

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ORGANIC LETTERS
卷 7, 期 18, 页码 3965-3968

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AMER CHEMICAL SOC
DOI: 10.1021/ol0514754

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  1. NIGMS NIH HHS [GM 58160] Funding Source: Medline
  2. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM058160] Funding Source: NIH RePORTER

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The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine.

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