期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 53, 期 1, 页码 79-82出版社
WILEY
DOI: 10.1111/j.1532-5415.2005.53014.x
关键词
adult-type hypolactasia; single-nucleotide polymorphism (SNP); bone fractures; elderly people
OBJECTIVES: To determine the relation between the C/T-13910 single-nucleotide polymorphism residing 13,910 base pairs from the 5' end of the lactase gene associated with lactase persistence and the occurrence of bone fractures in elderly people. DESIGN: Population-based study. SETTING: Vantaa 85+ population-based study, including all 601 subjects born before April 1, 1906, who were living in the city of Vantaa, Finland, on April 1, 1991. PARTICIPANTS: Four hundred eighty-three people aged 85 and older (106 men and 377 women). MEASUREMENTS: Genotype determination was made using a polymerase chain reaction minisequencing technique. RESULTS: The frequency of the genotype C/C-13910 associated with adult-type hypolactasia (low lactase enzyme activity or primary lactose malabsorption (LM)) was significantly greater in individuals with hip fractures, with an adjusted odds ratio (OR) of 3.7 (95% confidence interval (CI)=1.8-7.8), wrist fractures with an adjusted OR of 2.5 (95% CI=1.2-5.2), and hip and wrist fractures combined with an adjusted OR of 4.1 (95% CI=2.0-8.3). CONCLUSION: The C/C-13910 genotype associated with primary LM could represent a genetic risk factor for bone fractures for elderly people.
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