期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 71, 期 1, 页码 39-45出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.71.1.39-45.2005
关键词
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Mutations designated gtaC and gtaE that affect et-phosphoglucomutase activity required for interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate were mapped to the Bacillus subtilis pgcA (yhxB) gene. Backcrossing of the two mutations into the 168 reference strain was accompanied by impaired alpha-phosphogiucomutase activity in the soluble cell extract fraction, altered colony and cell morphology, and resistance to phages phi29 and rho11. Altered cell morphology, reversible by additional magnesium ions, may be correlated with a deficiency in the membrane glycolipid. The deficiency in biofilm formation in gtaC and gtaE mutants may be attributed to an inability to synthesize UDP-glucose, an important intermediate in a number of cell envelope biosynthetic processes.
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