期刊
INFECTION AND IMMUNITY
卷 73, 期 1, 页码 609-611出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.1.609-611.2005
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资金
- PHS HHS [R01-03915] Funding Source: Medline
We transformed a nontypeable Haemophilus influenzae clinical isolate with a plasmid containing the luxCDABE operon driven by the H. influenzae outer membrane protein P2 promoter. Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.
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