期刊
BIOPOLYMERS
卷 80, 期 2-3, 页码 98-150出版社
WILEY
DOI: 10.1002/bip.20213
关键词
conformational constraint; azacycloalkane amino acid; mimicry; peptide secondary structure; dipeptide; biological activity; enzyme inhibitor; receptor ligand
Azabicyclo [X.Y.O] alkanone amino acids are challenging synthetic targets and useful tools for studying structure-activity relationships of native peptide ligands. They have been employed to increase potency mid stability in conformationally rigid enzyme inhibitors and receptor ligands. Since last reviewed in 1997, activity in their synthesis and application has increased significantly and access is now available to a wider diversity of these peptide mimics. This review focuses on recent syntheses of these heterocyclic amino acids and their application in the investigation of biologically active peptides and peptide mimics. (c) 2005 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据