期刊
IMMUNOBIOLOGY
卷 210, 期 10, 页码 735-741出版社
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2005.10.003
关键词
anticardiolipin antibodies; antiphospholipid antibodies; antiphospholipid syndrome; infections; lupus anticoagulant
类别
Antiphospholipid antibodies (aPL) were originally detected in human serum almost 100 years ago when the Venereal Disease Research Laboratory (VDRL) test was described. A phospholipid called cardiolipin was the major tissue extract utilized in performing these tests. In 1983, cardiolipin was used for the first time as the antigen in solid-phase aPL specific assays for the now termed antiphospholipid syndrome (APS). Since then, many infections have been found to be associated with aPL positivity, although a pathogenic role for these antibodies was not usually obvious except in a few isolated cases. (C) 2005 Elsevier GmbH. All rights reserved.
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