期刊
BIOPOLYMERS
卷 80, 期 6, 页码 747-761出版社
WILEY
DOI: 10.1002/bip.20300
关键词
peptides and peptidomimetics; carbohydrates and cyclodextrins; sugar amino acids; carbopeptides and carboproteins
Monosaccharides and amino acids are fundamental building blocks in the assembly of nature's polymers. They have different structural aspects and to a significant extent, different functional groups. Oligomerization gives rise to oligosaccharides and peptides, respectively. While carbohydrates and peptides can be found conjoined in nature, e.g., in glycopeptides, the aim of this review is the radical redesign of peptide structures using carbohydrates, particularly monosaccharides mid cyclic oligosacchorides. to produce novel peptides, peptidomimetics, and abiotic proteins. These hybrid molecules, chimeras, have properties arising largely from the combination of structural characteristics of carbohydrates with the functional group diversity of peptides. This field includes de novo designed synthetic glycopeptides, sugar (carbohydrate) amino acids, carbohydrate scaffolds for nonpeptidal peptidomimetics of cyclic peptides, cyclodextrin functionalized peptides, and carboproteins, i.e., carbohydrate-based proteinmimetics. These successful applications demonstrate the general utility of carbohydrates in peptide and protein architecture. (c) 2005 Wiley Periodicals, Inc.
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