期刊
NEUROSCIENCE
卷 131, 期 1, 页码 1-11出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2004.09.066
关键词
extracellular recording; stereotrode; tetrode; multi-channel electrode; spike sorting; unit isolation
资金
- NIMH NIH HHS [MH68029, MH73245] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH073245, R01MH068029] Funding Source: NIH RePORTER
While the use of multi-channel electrodes (stereotrodes and tetrodes) has allowed for the simultaneous recording and identification of many neurons, quantitative measures of the quality of neurons in such recordings are lacking. In multi-channel recordings, each spike waveform is discriminated in a high-dimensional space, making traditional measures of unit quality inapplicable. We describe two measures of unit isolation quality, L-ratio and Isolation Distance, and evaluate their performance using simulations and tetrode recordings. Both measures quantified how well separated the spikes of one cluster (putative neuron) were from other spikes recorded simultaneously on the same multichannel electrode. In simulations and tetrode recordings, both L-ratio and Isolation Distance discriminated well- and poorly-separated clusters. In data sets from the rodent hippocampus in which neurons were simultaneously recorded intracellularly and extracellularly, values of Isolation Distance and L-ratio were related to the correct identification of spikes. (C) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.
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