期刊
NEUROIMAGE
卷 27, 期 3, 页码 479-496出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2005.04.037
关键词
acupuncture; negative BOLD; limbic; cerebrum; cerebellum; sensations; pain; affect; cognition
资金
- NCCIH NIH HHS [R21AT00978, K01-AT-002166-01] Funding Source: Medline
- NCRR NIH HHS [P41RR14075] Funding Source: Medline
- NINDS NIH HHS [NS 34189] Funding Source: Medline
- PHS HHS [1-P01-002048-01] Funding Source: Medline
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [K01AT002166, R21AT000978] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR014075] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034189] Funding Source: NIH RePORTER
Clinical and experimental data indicate that most acupuncture clinical results are mediated by the central nervous system, but the specific effects of acupuncture on the human brain remain unclear. Even less is known about its effects on the cerebellum. This fMRI study demonstrated that manual acupuncture at ST 36 (Stomach 36, Zusanli), a main acupoint on the leg, modulated neural activity at multiple levels of the cerebro-cerebellar and limbic systems. The pattern of hemodynamic response depended on the psychophysical response to needle manipulation. Acupuncture stimulation typically elicited a composite of sensations termed deqi that is related to clinical efficacy according to traditional Chinese medicine. The limbic and paralimbic structures of cortical and subcortical regions in the telencephalon, diencephalon, brainstem and cerebellum demonstrated a concerted attenuation of signal intensity when the subjects experienced deqi. When deqi was mixed with sharp pain, the hemodynamic response was mixed, showing a predominance of signal increases instead. Tactile stimulation as control also elicited a predominance of signal increase in a subset of these regions. The study provides preliminary evidence for an integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 that correlates with the psychophysical response. (c) 2005 Elsevier Inc. All rights reserved.
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