期刊
THROMBOSIS AND HAEMOSTASIS
卷 93, 期 1, 页码 88-91出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH04-06-0391
关键词
Paroxysmal Nocturnal Hemoglobinuria (PNH); ethnicity thrombosis; hypercoagulable states; deep venous thrombosis
资金
- NHLBI NIH HHS [R01 HL56778-06] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL056778] Funding Source: NIH RePORTER
Paroxysmal Nocturnal Haemoglobinuria (PNH) results in a marked thrombophilic state by unknown mechanisms. Geographic differences in thrombosis incidence in PNH have been observed. We have reviewed 64 patients with Classic PNH from a single institution in order to determine the rate of thrombosis in different ethnic groups. When we compared African-Americans (n=11) and Latin-Americans (n=8) with other patients (n=45), we found that African-American and Latin-American patients are at increased risk [Hazard ratio, 3.66 (p=0.005) and 3.52, (p=0.035) respectively by Cox regression]. Our data also suggest that this difference in the rate of thrombosis has an impact on length of survival. These findings demonstrate that ethnicity is a risk factor for thrombosis in PNH and have implications for decision-making regarding the management of these patients, including the prevention of thrombosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据