Kinetic resolution of sec-alcohols using a new class of readily assembled (S)-proline-derived 4-(pyrrolidino)-pyridine analogues

We report the development of a new class of readily prepared chiral 4-( pyrrolidino)- pyridine catalysts capable of exploiting both van der Waals (pi) and H- bonding interactions, thus allowing remote chiral information to stereochemically control the kinetic resolution of sec-alcohols.