期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 96, 期 1-2, 页码 195-200出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2004.09.008
关键词
New Caledonian and Vanuatu medicinal plants; Amborella trichopoda tuberculosis; Mycobacterium bovis
Twenty plants, belonging to sixteen families, used in traditional New Caledonian and Vanuatu medicine for treatment of symptoms potentially related to tuberculosis (cough, fever or inflammation) were screened for anti mycobacterial activity. We also screened an original endemic plant, Amborella trichopoda, only member of the monogeneric family Amborellaceae and considered the most primitive living angiosperm. In total, 55 extracts were evaluated for inhibitory activity against Mycobacterium bovis BCG strain at a concentration of 100 mug/ml. Methanolic and dichloromethane extracts of Amborella trichopoda, Codiaeum peltatum, Myristica fatua, and essential oils Myoporum crassifolium showed an activity at this concentration. Methanolic extract of Amborella trichopoda fruits presented a significant activity with a minimal inhibitory concentration included between 1 and 2.5 mug/ml. In the same conditions, this activity was comparable with those of the reference drugs pyrazynamide and ethambutol, at 20 and 2.5 mug/ml, respectively. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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