期刊
BIOMACROMOLECULES
卷 6, 期 1, 页码 220-228出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm049551y
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资金
- NIGMS NIH HHS [5-T32-GM08785-02] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008785] Funding Source: NIH RePORTER
Hybrid peptidic-synthetic amphiphilic block copolymers, synthesized by living free radical Polymerization (LFRP) on solid support, have been utilized as precursors for nanoscale materials possessing bio-available peptides. LFRP initiators, coupled to the peptide terminus upon the resin, facilitated the growth of homo-and block copolymers via nitroxide mediated radical polymerization (NMRP) or atom transfer radical polymerization (ATRP). Herein, the versatile solid-support synthesis of the antimicrobial peptide tritrpticin, coupling of living free radical polymerization initiators to the peptide-loaded resin, and the controlled radical polymerization of various monomers to yield amphiphilic diblock copolymers are described. Assembly of the peptidic-synthetic block copolymers into micelles and a preliminary assessment of their in vitro biological properties are detailed.
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