期刊
AMERICAN HEART JOURNAL
卷 149, 期 1, 页码 13-19出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ahj.2004.07.001
关键词
-
Background Patients with diabetes have an increased incidence and severity of. ischemic heart disease, which leads to an increased requirement for coronary revascularization. Comparative information regarding mode of revascularization- coronary artery bypass graft surgery surgery (CABG) or percutaneous coronary intervention (PCI)-is limited, mainly confined to a subanalysis of the Bypass Angioplasty Revascularization (BARI) trial, suggesting a mortality benefit of CABG over PCI. No prospective trial has specifically compared these mode's of revascularization in patients with diabetes. Objective The Coronary Artery Revascularisation in Diabetes (CARDia) trial is designed to address the hypothesis that optimal PCI is not inferior to modern CABG as a revascularization strategy for diabetics with multivessel or complex single-vessel coronary disease. The primary end point is a composite of death, nonfatal myocardial infarction, and cerebrovascular accident at 1 year. Method A total of 600 patients with diabetes are to be randomized to either PCI or CABG, with few protocol restrictions on operative techniques or use of new technology.'This gives a power of 80% to detect non-inferiority of PCI assuming. that the PCI 1-year event rate is 9%. A cardiac surgeon and a cardiologist must agree that a patient is suitable for revascularization by either technique prior to recruitment into the study. Twenty-one centers in the United Kingdom and Ireland are recruiting patients. Data on cost effectiveness, quality of life, and neurocognitive function are being collected. Long-term (3-5 year) follow-up data will also be collected.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据